Publications

SCIENTIFIC PUBLICATIONS:

  1. Liu, C, Xu, D, Sjöberg, J, Forsell, P, Björkholm, M. and Claesson, H-E: Transcriptional regulation of 15-lipoxygenase expression by promoter methylation. Experimental Cell Res. 297, 61-67 (2004)
  2. Runarsson, G, Liu, A, Mahshid, Y, Feltenmark, S, Pettersson, A, Klein, E, Björkholm, M and Claesson, H-E: Leukotriene B4 plays a pivotal role in CD40-dependent activation of Chronic B lymphocytic leukemia cells. BLOOD 105, nr.3, 1274-1279 (2005)
  3. Anderssson, E, Schain, F, Svedling, M, Claesson, H-E and Forsell, P: Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity. Biochem. Biophys. Acta. 1761, 1498-1505 (2006)
  4. Gulliksson M, Brunnström A, Johannesson M, Backman L, Nilsson G, Harvima I, Dahlén B, Kumlin M, Claesson H-E: Expression of 15-lipoxygenase type-1 in human mast cells.
    Biochim Biophys Acta. 2007 Sep;1771(9):1156-65.
  5. Runarsson G, Feltenmark S, Forsell PK, Sjöberg J, Björkholm M, Claesson H-E: The expression of cytosolic phospholipase A2 and biosynthesis of leukotriene B4 in acute myeloid leukemia cells.
    Eur J Haematol. 2007 Dec;79(6):468-76.
  6. Carvalho RF, Mahshid Y, Claesson H-E, Glimelius I, Fischer M, Nilsson G: Expression of mast cell tryptases in Hodgkin and Reed-Sternberg (HRS) cells.
    Scand J Immunol. 2008 Jan;67(1):53-6. Epub 2007 Nov 16.
  7. Feltenmark S, Gautam N, Brunnström A, Griffiths W, Backman L, Edenius C, Lindbom L, BjörkholmM,  Claesson H-E: Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.
    Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):680-5.
  8. Liu A, Claesson H-E, Mahshid Y, Klein G, Klein E: Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures.
    Blood. 2008 Mar 1;111(5):2693-703.
  9. Klein E, Liu A, Claesson H-E: Activation of innate immunity by the leukotriene B 4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures.
    Immunol Lett. 2008 Mar 15;116(2):174-7.
  10. Andersson CK, Claesson H-E, Rydell-Törmänen K, Swedmark S, Hällgren A, Erjefält JS: Mice lacking 12/15-lipoxygenase have attenuated airway allergic inflammation and remodeling.
    Am J Respir Cell Mol Biol. 2008 Dec; 39(6):648-56.
  11. Claesson H-E, Griffiths WJ, Brunnström A, Schain F, Andersson E, Feltenmark S, Johnson HA, Porwit A, Sjöberg J, Björkholm M: Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
    FEBS J. 2008 Aug;275(16):4222-34.
  12. Schain F, Tryselius Y, Sjöberg J, Porwit A, Backman L, Malec M, Xu D, Vockerodt M, Baumforth KR, Wei W, Murray PG, Björkholm M, Claesson H-E: Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma.
    Int J Cancer. 2008 Nov 15;123(10):2285-93.
  13. Schain F, Schain D, Mahshid Y, Liu C, Porwit A, Xu D, Claesson HE, Sundström C, Björkholm M, Sjöberg J: Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.
    Clin Lymphoma Myeloma. 2008 Dec; 8(6):340-7.
  14. Mahshid Y, Lisy MR, Wang X, Spanbroek R, Flygare J, Christensson B, Björkholm M, Sander B, Habenicht AJ, Claesson H-E: High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes.
    BMC Immunol. 2009 Jan 9;10:2.
  15. Gheorghe KR, Korotkova M, Catrina AI, Backman L, af Klint E, Claesson H-E., Rådmark O,  Jakobsson PJ: Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
    Arthritis Res Ther. 2009;11(3):R83.
  16. Liu C, Xu D, Liu L, Schain F, Brunnström A, Björkholm M, Claesson HE, Sjöberg J: 15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
    Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L196-203.
  17. Claesson H-E: On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma (review).Prostaglandins Other Lipid Mediat. 2009 Sep; 89(3-4):120-5.
  18. Mutule I, Suna E, Olofsson K, Pelcman B: Catalytic direct acetoxylation of indoles.
    J Org Chem. 2009  74(18):7195-8.
  19. Sundell-Bredenberg S, Nyström C: The possibility of achieving an interactive mixture with high dose homogeneity containing an extremely low proportion of a micronised drug.
    Eur. J. Pharm. Sci. 2001,12, 285-295.
  20. Bredenberg S, Nyström, C: In vitro evaluation of bioadhesion in particulate systems and possible improvement using interactive mixtures.
    J. Pharm. Pharmacol. 2003, 55, 169-177.
  21. Bredenberg S, Duberg M, Lennernäs B, Lennernäs H., Pettersson A, Westerberg M, Nyström C: In vitro and pharmacokinetic evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance.
    Eur. J. Pharm. Sci. 2003, 20, 327-334.
  22. Lennernäs B, Hedner T, Holmberg M, Bredenberg S, Nyström C, Lennernäs H: Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain. Br. J. Clin. Pharmacol. 2005, 59, 249-253.
  23. Fransén N, Bredenberg S, Björk E: Clinical study shows improved absorption of desmopressin with novel formulation.
    Pharm. Res., 26 2009, 1618-1625.
  24. Forsgren J, Jämstorp E, Bredenberg S, Engqvist H, Strømme M: A ceramic drug delivery vehicel for oral administration of highly potent opioids.
    J. Pharm. Sci. 2009 in press doi:10.1002/jps.21814
  25. Nyström C and Westerberg M: Physicochemical aspects of drug release II. The use of ordered mixtures for improving the dissolution rate of low solubility compounds.
    J. Pharm. Pharmacol., 38 (1986) 161-165.
  26. Westerberg M, Jonsson B and Nyström C: Physicochemical aspects of drug release IV. The effect of carrier particle properties on the dissolution rate from ordered mixtures.
    Int. J. Pharm., 28 (1986) 23-31.
  27. Nilsson P, Westerberg M and Nyström C: Physicochemical aspects of drug release V. The importance of surface coverage and compaction on drug dissolution from ordered mixtures.
    Int. J. Pharm., 45 (1988) 111-121.
  28. Westerberg M and Nyström C: Physicochemical aspects of drug release XII. The effect of some carrier particle properties and lubricant admixture on drug dissolution from tableted ordered mixtures.
    Int. J. Pharm., 69 (1991) 129-141.
  29. Westerberg M and Nyström C: Physicochemical aspects of drug release XVII. The effect of drug surface area coverage to carrier materials on drug dissolution from ordered mixtures.
    Int. J. Pharm., 90 (1993) 1-17.
  30. Westerberg M and Nyström C: Physicochemical aspects of drug release XVIII. The use of a surfactant and a disintegrant for improving drug dissolution rate from ordered mixtures.
    S.T.P. Pharma Sciences, 3 (1993) 142-147. 

THESES

  1. Biosynthesis and Biological Role of Leukotrienes in Human Lymphocytes
    Yilmaz Mahshid, April 2009
  2. Studies on the Activation of Cytosolic Phospholipase A2 and 15-lipoxygenase-1 in Hematopoietic Cells
    Erik Andersson, April 2009
  3. New concepts in administration of drugs in tablet form – Formulation and evaluation of a sublingual tablet for rapid absorption, and presentation of an individualised dose administration system
    Susanne Bredenberg, 2003
  4. Studies on a Novel Powder Formulation for Nasal Delivery
    Nelly Fransén, 2008
  5. Studies on ordered mixtures for fast release and dissolution of drugs with low aqueous solubility
    Marie Westerberg, 1992